The present invention generally relates to the transdermal delivery of various compositions. In some aspects the transdermal delivery may be facilitated by the use of a hostile biophysical environment. One set of embodiments provides a composition for topical delivery comprising ibuprofen and/or an ibuprofen salt a nitric oxide donor and optionally a hostile biophysical environment. In some cases the composition may be stabilized using a stabilization polymer such as xanthan gum KELTROL� BT and/or KELTROL� RD; propylene glycol; and a polysorbate surfactant such as Polysorbate 20 which unexpectedly provides temperature stability to the composition e.g. at elevated temperatures such as at least 40� C. (at least about 104� F.) as compared to compositions lacking one or more of these.

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