595024 Disclosed herein is a compound which is NN-dimethyl-5-(2-methyl-6-((5-methylpyrazin-2-yl)carbomoyl-4-yloxy)pyrimidine-2-carboxamide a pharmaceutical composition comprising it and a pharmaceutical composition further comprising an anti-obesity agent and an anti-diabetic agent. Wherein said anti-obesity agent is selected from the group consisting of dirlotapide mitratapide implitapide lorcaserin cetilistat PYY3-36 naltrexone oleoyl-estrone obinepitide pramlintide tesofensine leptin liraglutide bromocriptine orlistat exenatide AOD-9604 (CAS No. 221231-10-3) and sibutramine. Wherein said anti-diabetic agent is selected from the group consisting of metformin acetohexamide chlorpropamide diabinese glibenclamide glipizide glyburide glimepiride gliclazide glipentide gliquidone glisolamide tolazamide tolbutamide tendamistat trestatin acarbose adiposine camiglibose emiglitate miglitol voglibose pradimicin-Q salbostatin balaglitazone ciglitazone darglitazone englitazone isaglitazone pioglitazone rosiglitazone troglitazone exendin-3 exendin-4 trodusquemine reservatrol hyrtiosal extract sitagliptin vildagliptin alogliptin and saxagliptin.

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