PROBLEM TO BE SOLVED: To provide a novel arteriosclerosis drug that controls infiltration of macrophage into an artery and is thereby capable of controlling thickening and fibrosis of aortic tunica media. SOLUTION: The arteriosclerosis drug includes nitroso nifedipine and a nitroso nifedipine derivative such as nitroso-nisoldipine nitroso-nimodipine nitroso-nicardipine and nitroso-nitrendipine nitroso nifedipine as active ingredients. The drug can control infiltration of macrophage into an artery that has a large influence on the progress of arteriosclerosis to control thickening and fibrosis of smooth muscle media of an arterial vessel. Thus the drug improves various symptoms of arteriosclerosis and is useful as prevention or a drug of a disease related to arteriosclerosis. COPYRIGHT: (C)2013JPO&INPIT

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