A disclosed preparation method for S-pantoprazole sodium comprises the following steps: (a) making S-pantoprazole suspend in a singular or mixed solvent; (b) adding an aqueous solution of sodium hydroxide stirring for reaction and further for precipitation of a solid; (c) performing separation and washing on the solid; and (d) drying to obtain S-pantoprazole sodium sesquihydrate. The invention also discloses a method for preparing amorphous S-pantoprazole sodium. The method comprises: (a) making S-pantoprazole suspend in a singular or mixed solvent; (b) adding an aqueous solution of sodium hydroxide stirring for reaction and further for precipitation of a solid; (c) performing separation and washing on the solid; and (d) drying to obtain amorphous S-pantoprazole sodium. The invention further discloses a method for preparing amorphous S-pantoprazole sodium. In the method amorphous S-pantoprazole sodium is obtained by drying S-pantoprazole sodium sesquihydrate. The methods of the invention have the advantages of economy simple operation stable product quality and high repeatability and are application to industrialized production.

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