598890 Disclosed herein are compounds of formula (I) U1-M-U2 wherein the variables are defined in the specification the use of said compounds in the treatment of cancer specifically by sensitising a cell to an apoptotic signal. Additionally said compounds may be used for sequential or concomitant use with a pharmaceutical compound which induces an apoptotic signal such as cytarabine fludarabine 5-fluoro-2'-deoxyuridine 5 gemcitabine methotrexate bleomycin cisplatin cyclophosphamide adriamycin (doxorubicin) mitoxantrone camptothecin topotecan colcemid colchicine paclitaxel vinblastine vincristine tamoxifen finasteride taxotere or mitomycin C or radiation.

暂无附图