The present invention relates to acetyl group L-carnitine or the acceptable salt of its pharmacy and be used to prevent purposes owing to the illeffects that uses the PPAR-gamma agonist to cause; Said illeffects is osteoporosis weight increase and edema for example; Said PPAR-gamma agonist is selected from spirolaxine or glitazone derivant and said glitazone derivant is selected from troglitazone pioglitazone and rosiglitazone.

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