The invention provides a kind of solid compound preparation that contains metformin hydrochloride and glimepiride described solid compound preparation is made by metformin hydrochloride granule and glimepiride granule in described metformin hydrochloride granule comprise metformin hydrochloride and binding agent in described glimepiride granule comprise glimepiride water ease of solubility filler disintegrating agent and binding agent in wherein said solid compound preparation do not comprise not ease of solubility filler of water.The present invention also provides preparation method and the purposes of above-mentioned solid compound preparation.Solid compound preparation of the present invention and ordinary preparation and adopt water not the preparation of ease of solubility filler compare can significantly improve the dissolution rate of glimepiride and effectively reduce the interaction of two kinds of principal agents thereby reduce the recruitment of related impurities in put procedure constant product quality and homogeneity are good improve effectiveness and the safety of patient's medication.

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