The present invention relates to enteric coatel tablets of a kind of S-pantoprazole or its salt and preparation method thereof wherein said enteric coatel tablets are comprised of following ingredients: label a) being comprised of S-pantoprazole or its salt and pharmaceutic adjuvant; B) sealing coat; C) enteric layer.The label of S-pantoprazole of the present invention or its salt is formed by direct compression of full-powder method compacting thereby has effectively avoided in wet granulation the destruction of high temperature to S-pantoprazole or its salt in moisture and particle drying process has improved the stability of preparation.In addition sealing coat and enteric layer composition are less prepare easy.The present invention has simplified preparation technology has reduced production cost and the S-pantoprazole enteric coatel tablets dissolution rate of preparation is better and stability is also fine.

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