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专利详细信息
专利号
EA3025B1
专利标题 Treatment of diabetes with thiazolidinedione and sulphonylures
专利权人 SMITHKLINE BEECHAM PLC;
发明人 Smith, Stephen Alistair;
申请号
申请日
公开日 2002/12/26
优先权号
IPC A61K04500000;
专利类型
法律状态查询 查看法律状态


1. A method for the treatment of diabetes mellitus and conditions associated with diabetes mellitus in a mammal with positive effect by glycemic control without observable unfavourable effects which method comprises administering 2 to 12 mg daily 5-[4-[2-(N-methyl-N-(2-pyridyl)amino)ethoxy]benzyl]thiazolidine-24-dione (Compound I) or a pharmaceutically acceptable salt thereof and sulfonyl urea. 2. A method according to Claim 1 wherein the c is glibenclamide glipizide gliclazide glimepiride tolazamide or tolbutamide. 3. A method according to any one of Claims 1 or 2 wherein the sulfonyl urea is glimepiride. 4. A method according to any one of Claims 1 to 4 which comprises the administration of 2 to 4 or 4 to 8 or 8 to 12 mg of Compound (I). 5. A method according to any one of Claims 1 to 4 which comprises the administration of 2 to 4 mg of Compound (I). 6. A method according to any one of Claims 1 to 4 which comprises the administration of 4 to 8 mg of Compound (I). 7. A method according to any one of Claims 1 to 4 which comprises the administration of 8 to 12 mg of Compound (I). 8. A method according to any one of Claims 1 to 4 which comprises the administration of 2 mg of Compound (I). 9. A method according to any one of Claims 1 to 4 which comprises the administration of 4 mg of Compound (I). 10. A method according to any one of Claims 1 to 4 which comprises the administration of 8 mg of Compound (I).
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