The invention discloses a kind of 4-(4-aminobenzene sulfonamide base) phenylacetic acid derivatives with following general formula in structure comprise benzsulfamide and toluylic acid structural unit.In Vitro Anti diabetic activity measurement result shows these compounds all have certain peroxisome proliferation-activated receptors (PPAR) agonist activity wherein the relatively exciting rate of PPAR of part of compounds (take pioglitazone as reference) surpasses 58% is up to 81.79%.These compounds can be used for preparing antidiabetic medicine and the guide's molecule that also can be used as novel antidiabetic thing is further furtherd investigate; The present invention also provides the method for preparing these compounds by many routes succinct efficient yield is high.

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