The invention provides a kind of method of the oral solid formulation for the preparation of comprising biguanides and acarbose described method comprises: 1) by described biguanides and pharmaceutically acceptable adjuvant wet granulation and by the dry biguanides granule of dry acquisition; With 2) by step 1) dried particles that makes directly mixes with acarbose and pharmaceutically acceptable adjuvant thereby makes described oral solid formulation.The present invention also provides the oral solid formulation that comprises biguanides and acarbose of being prepared by said method.

暂无附图