The present invention relates to a kind of Glipizide controlled release compositions by double-deck label and semipermeable membrane controlled release coat film formed described double-deck label is comprised of medicated layer and boosting layer and wherein coating membrane is prepared by the intermittent spray pattern of coating solution concrete steps are: 1. prepare coating solution 2. coating solution spraying 3. uses water spray is 4. dried to remove and anhydrates 5. repetitive operation 2.～4. until coating membrane weightening finish meets the requirements.The invention still further relates to a kind of preparation method of Glipizide controlled release compositions comprise medicated layer granulation the granulation of boosting layer double-deck label preparation coating and laser boring wherein coating process is intermittent spray coating.The present invention is by controlling coating solution filmogen content in solvent the content of water acetone and packaging technique method realized and having produced in coating membrane organic solvent residual low the effect that appearance transparence is high its preparation method is simple is conducive to industrial applications.

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