The present invention relates to Pantoprazole Sodium specifically relate to a kind of Pharmaceutical composition of Pantoprazole Sodium.In described pharmaceutical composition contain Pantoprazole Sodium sodium chloride and excipient wherein Pantoprazole Sodium: sodium chloride: the weight ratio of excipient is 10:1～5:5～20 preferably 10:1～3:8～16.Described excipient is selected from least one in mannitol glucose dextran sorbitol lactose preferably mannitol or sorbitol.Pantoprazole Sodium Pharmaceutical composition impurity content of the present invention is low and stability is high is applicable to clinical practice.

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