PURPOSE: A pharmaceutical composition containing a thiazolidinedione-based drug for preventing and treating Alzheimer's disease is provided to enhance LRP1 expression and the discharge of beta-amyloid into the blood. CONSTITUTION: A pharmaceutical composition for treating neurological disorders contains a thiazolidinedione-based drug as an active ingredient. The thiazolidinedione-based drug includes rosiglitazone pioglitazone or troglitazone. The pharmaceutical composition enhances the LRP1 expression level in the cerebrovascular endothelial cells. The pharmaceutical composition enhances the absorption of beta-amyloid by LRP1. The composition is a capsule a tablet a granule an injection an ointment a powder or a beverage. A health functional food for preventing or treating neurological disorders contains a thiazolidinedione-based drug as an active ingredient.

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