PURPOSE: A composition containing Dendrobium moniliforme is provided to prevent relieve or treat PPAR activation regulation-related diseases including obesity metabolic diseases and cardiovascular diseases. CONSTITUTION: A composition for preventing or treating PPAR activation regulation-related diseases contains Dendrobium moniliforme as an active ingredient. A composition for health functional food for preventing or treating PPAR activation regulation-related diseases contains Dendrobium moniliforme as an active ingredient. Dendrobium moniliforme is used as pulverized Dendrobium moniliforme a dried material thereof or a crude extract prepared by using a solvent which is selected from water C1-C4 alcohol and a combination thereof. The C1-C4 alcohol is methanol or ethanol. Dendrobium moniliforme is also used as a fraction which is prepared from the crude extract using n-hexane methylene chloride or ethyl acetate. [Reference numerals] (AA) Relative value(%); (BB) No treatment group Troglitazone; (CC) Example ; (DD) Example ; (EE) Example n-Hx; (FF) Example MC; (GG) Example EA; (HH) Example fr2; (II) Example fr3; (JJ) Example fr2-2; (KK) Example fr2-5; (LL) Example compound 1; (MM) Example compound 2; (NN) Example compound 3; (OO) Example compound 4

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