The present invention discloses a kind of Lansoprazole composition enteric coated capsule described enteric coated capsule comprises the component of following weight portion: lansoprazole 20-30 part sodium bicarbonate 12-18 part calcium hydrogen phosphate 15-20 part magnesium hydroxide 10-20 part enteric coating agents 25-30 part filler 60-100 part disintegrating agent 20-30 part binding agent 20-25 part lubricant 20-25 part 50% alcoholic solution 400-500 part.Lansoprazole composition enteric coated capsule safety of the present invention effective storage-stable efficient stripping in intestinal juice.In addition the present invention also discloses a kind of preparation method of Lansoprazole composition enteric coated capsule and described method preparation technology is simple easy to operate and favorable reproducibility is applicable to suitability for industrialized production.

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