The present invention relates to a kind of Glipizide controlled release compositions double-deck label and semipermeable membrane controlled release coat film consist of double-deck label is comprised of medicated layer and boosting layer and compositions medicated layer boosting layer are used aqueous suspension to granulate.The invention still further relates to a kind of preparation method of Glipizide controlled release compositions comprise medicated layer granulation the granulation of boosting layer double-deck label preparation coating and punching wherein medicated layer and boosting layer are used aqueous suspension to granulate.Glipizide controlled release composition grain prepared by the present invention is evenly distributed tabletting in flakes effective content is even organic solvent residual rate is low result of extraction is good preparation method is simple is conducive to industrial applications.

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