The invention discloses a kind of granule that contains omeprazole by weight comprise 1 part of omeprazole sodium bicarbonate 27.5-55 part lubricant 0-2 part; The invention also discloses its preparation method: first will comprise 1 part of omeprazole 5-25 part sodium bicarbonate and 0-0.4 part lubricant mix homogeneously dry granulation makes fine grained; Again adjuvant and the aforementioned fine grained making of prescription surplus are mixed to rear dry granulation granulation; Wherein omeprazole particle diameter is less than 65 μ m.This preparation method adopts dry granulation secondary embedding.The unstable crystal formation of the omeprazole technical problems such as variable color and lay up period catabolite showed increased of easily degrading have been solved in existing technical process.Prescription provided by the invention technique are simple can be used for industrialized great production.

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