The present invention relates to a kind of preparation method of glipizide osmotic pump controlled release tablet comprise that the glipizide label will prepared makes through wrapping semi-transparent rete laser boring and bag damp-proof layer it is characterized in that preparing the glipizide label and comprise and prepare solid dispersion and prepare label.The solid dispersion technology that the present invention adopts has significantly improved the dissolution velocity of medicine and the adjuvant of hydrotropy has improved the dissolubility of glipizide and adds in right amount short penetrating agent to regulate osmotic pressure to reach constant speed or approach constant release.The present invention has advantages of that technique is simple cost is low patient easily accepts and therapeutic effect is good.

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