The present invention has announced a kind of synthesis technique of preparing gliclazide with low-cost raw material high yield.Comprise following reactions steps: the first step 1 the adjacent dicarboxylic acid anhydride of 2-pentamethylene reacts preparation N-ammonia-1 with hydrazine hydrate the adjacent diformamide of 2-basic ring pentane; Second step N-amino-1 the reduction of the adjacent diformamide of 2-pentamethylene; The 3rd step tolylsulfonylurea reacts preparation gliclazide with upper step reduzate.The present invention is from 1 of cheapness and the adjacent dicarboxylic acid anhydride of 2-pentamethylene sets out and uses NaBH4/ dense H2sO4reduction system N-amino-1 the adjacent diformamide of 2-pentamethylene avoids using expensive reagent LiAlH4 therefore production cost reduces greatly.

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