The invention provides a kind of omeprazole nanoemulsions and preparation method thereof described emulsion is respectively omeprazole 0.1-1% by percentage by weight surfactant 16-30% cosurfactant 0.15-20% oil 2-25% the component of water for injection 34-50% forms described omeprazole nanoemulsions thermodynamic stability is good can recover stable Emulsion state completely being heated to place abundant vibration after 80 ℃ excellent storage stability be long placed in not stratified not only Orally-administrable but also can intramuscular administration especially oral administration nano-emulsion substrate can protect omeprazole be not subject to the destruction of gastric acid and can overcome liver first-pass effect well its preparation method is simple is applicable to the needs that large-scale industrial is produced.

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