The present invention discloses a kind for the treatment of diabetes compound medicine that reduces the rosiglitazone side effect and preparation method thereof belongs to medical preparation field.This compound medicine is made up of rosiglitazone and diuretic and wherein the proportioning of rosiglitazone and diuretic is 1: 0.04～1 by weight.This treatment diabetes compound medicine is by cooperating in spironolactone that can the side effect of fine elimination rosiglitazone amiloride compound recipe amiloride ergosterol triamterene etacrynic acid hydrogen fluorine first thiophene the bumetanide any with the rosiglitazone compound recipe formation had not only reduced the side effect of rosiglitazone but also compound medicine that can fine treatment diabetes.

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