The present invention relates to formulation art be specifically related to a kind of lansoprazole intestine dissolving capsule and preparation method thereof.Technical problem solved by the invention has been to provide a kind of lansoprazole intestine dissolving capsule and preparation method thereof has reduced the fussy degree of existing technique realizes in small intestinal position Stable Release steady quality is reliable bioavailability is high object.The key problem in technology point of lansoprazole intestine dissolving capsule of the present invention is that the capsule material of microcapsule is selected and control capsule core material particle diameter.The capsule heart and capsule material weight proportion are as follows: the capsule heart: lansoprazole micropowder 45-50 part; Capsule material: chitosan 4-6 part; Arabic gum 2-4 part; Hydroxypropyl Methylcellulose Phathalate 3-5 part.Capsule core material of the present invention is micronized lansoprazole bulk drug the preferred 95%

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