The invention discloses a kind of gliclazide sheet formed by gliclazide solid dispersion granule and acceptable accessories direct compression; Described gliclazide solid dispersion granule is prepared from as follows: the heating and melting in the hot melt extruder with citric acid and polyvinyl acetate adds the gliclazide fusion then with the fused solution extrusion granulator.Preparation production technique of the present invention is simple and the patient only need take 1 time every day simultaneously and active component slowly discharged in vivo after the patient took medicine blood drug level is steady have more long-lasting thereby reduced the number of times of medication reduced toxic and side effects and the treatment cost declines to a great extent also.

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