The present invention relates to a kind of stable omeprazole sodium medicinal composition comprise Omeprazole Sodium domperidone cosolvent histidine and be selected from mannitol and the excipient of sorbitol the pH of its solution is 10～11.It is cosolvent that said composition adopts histidine not only can improve the dissolubility of domperidone but also can play stabilizer function can not use the stabilizing agents such as EDTA and salt thereof just can make Omeprazole Sodium stable.

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