The invention discloses a kind of gliclazide intra-gastric floating tablet it comprises following component and the weight ratio of each component is: gliclazide 5～15 gel rubber material 20～60 wax material 20～50 foaming material 1～10 lactose 15～40 magnesium stearate 1～5 PVPK300～5; Also announced the preparation method of gliclazide intra-gastric floating tablet.The invention has the beneficial effects as follows: because the gliclazide intra-gastric floating tablet can keep floating state in gastric juice gastric transit time is 8～12 hours and lasting release in the gastric juice environment of acidity therefore release is constant fully and has improved the bioavailability of medicine reduces dosage and medicining times promote drug absorption at specific part alleviated toxic and side effects.

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