The invention discloses the preparation method of a kind of gliclazide intermediate pimelinketone-2-methane amide.Add the volution thing in 9.1 ~ 9.8% the dilute sulphuric acid for preparing heat up and steam water and pimelinketone mixed fraction when there is no pimelinketone in cut continue to steam water to 65～80% of total Water standing demix after telling following water layer above oil reservoir put into esters solvent temperature rising reflux half an hour be cooled to insulation below 10 ℃ 2 hours suction filtration washing oven dry gets white or beige pimelinketone-2-methane amide crystalline powder.Synthesis technique of the present invention is simple to operate and reaction conditions is gentle and product purity is high and yield is high is fit to suitability for industrialized production.

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