The invention discloses a famotidine injection and a preparation method thereof. The preparation is prepared by the following steps: dissolving famotidine into the molten liquid of 15-polyethylene glycol hydroxystearate and mixing with an osmotic pressure regulator a pH regulator and injection water wherein the pH value of the injection is regulated to 6.5-7.5 by the pH regulator. According to the famotidine injection and preparation method thereof disclosed by the invention the solubility of famotidine in a neutral environment is improved by adopting 15-polyethylene glycol hydroxystearate so as to improve the stability of active ingredients; the preparation technology is simple and is suitable for industrial mass production.

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