The present invention relates to technical field of organic synthesis be specifically related to a kind of preparation method of pharmaceutical intermediate tolylsulfonylurea it is characterized in that: take p-toluol sulfonamide (also claiming the 4-methyl benzenesulfonamide) as starting raw material with NaOH and urea through single step reaction do not add any reaction solvent adopt scorification namely to be commonly called as dry method synthetic tolylsulfonylurea.It is the important intermediate of synthetic sulfourea oral antidiabetic drug tolbutamide and gliclazide.

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