The present invention relates to a kind of externally used compound medicine for the treatment of acne.It is characterized in that: contain following active ingredients in the medium carrier of externally used compound medicine: NSAID (non-steroidal anti-inflammatory drug) cimetidine antimicrobial drug.The invention has the advantages that: its three kinds of active component act on a plurality of links (antiinflammatory antibiotic minimizing sebum secretion) of acne pathological process simultaneously thereby have improved acne especially the curative effect of acne; This externally used compound drug safety is big nonirritant and anaphylaxis; Contained active component is inexpensive be easy to get and finished medicines can be accepted by vast patients with acne surely.

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