The present invention relates to injecting drug use disclose a kind of injection omeprazole sodium compositions the each component that comprises following weight quota: 40 parts of Omeprazole Sodiums 35 parts of mannitol 3-5 part vitamin B63-5 part thioctic acid and appropriate pH value regulate reagent.The invention also discloses the method for this injection omeprazole sodium compositions of preparation comprise that (1) is just molten; (2) dosing; (3) adsorption filtration; (4) fill; (5) sublimation drying; (6) processed finished products.Product of the present invention has the not allochroic advantage of stability height.

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