The present invention relates to formulation art be specifically related to a kind of Lansoprazole enteric pellet capsule and preparation method thereof.Technical problem solved by the invention is to provide the Lansoprazole enteric pellet capsule that a kind of more stable quality is controlled human body use is more safe and reliable.Comprise micropill and capsule shells; Micropill is that micropill contains the pill heart and wraps successively contagion gown layer and enteric coating layer; Wherein (1) micropill containing pill heart weight proportion is: 5～20 parts of lansoprazoles 30～80 parts of celphere 0.5～2 part of pH adjusting agent 1～3 part of binding agent 25～45 parts water; Preferred D95=5～8 of lansoprazole micronization particle size range μ m; (2) contagion gown layer is the mixture of filler binding agent filler: binder wt is than being 1:2～1:6; Or be stomach dissolution type Opadry; (3) enteric coating layer containing film former porogen film former: porogen weight ratio is 1:18～1:24; Or be enteric solubility Opadry.

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