The invention provides complex tablet of a kind of famotidine and (S)-ibuprofen and preparation method thereof the described complex tablet right side is comprised of (S)-ibuprofen famotidine disintegrating agent diluent binding agent lubricant and fluidizer and the weight ratio of described famotidine and described (S)-ibuprofen is 1:(29 ~ 31).Described preparation method comprises the following steps: after mixing with diluent disintegrating agent by famotidine add binding agent wet granulation dries and prepares famotidine granule; (S)-ibuprofen and diluent disintegrating agent are mixed with (s)-ibuprofen granules; Described famotidine granule and described (s)-ibuprofen granules are mixed obtain hybrid particles I; In described hybrid particles I add lubricant and fluidizer mix obtain hybrid particles II; Compress described hybrid particles II form tablet.The present invention has advantages of that better efficacy onset are faster consumption is few directly oral medication adult's rheumatoid arthritis and osteoarthritis.

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