The invention discloses a kind of synthetic method of type II diabetes medicine glimepiride intermediate benzene sulfanilamide (SN) triphosgene by N-4-［ 2-(3-ethyl-4-methyl-2-oxidation-3-pyrroline-1-formamido-) ethyl ］-benzsulfamide with oppose that methylcyclohexyl amine is in solvent under acid binding agent exists control certain temperature slowly drip triphosgene post-reaction treatment and obtain target product.Technique of the present invention is simple easy to operate and product yield is high and it is safer that phosgene is compared in the use of solid phosgene (triphosgene) convenient operation.

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