Described are pharmaceutical compositions comprising phentermine metformin and at least one pharmaceutically acceptable carrier or excipient. Another aspect of the present invention relates to a method of treating a patient suffering from obesity or needing to lose weight comprising the step of co-administering to said patient a therapeutically effective amount of phentermine and metformin. In certain embodiments an aforementioned method is practiced in conjunction or tandem with a medical procedure or the use of a medical device or both.

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