The invention discloses a kind of ranitidine hydrochloride bismuth potassium citrate pharmaceutical composition solid lipid nano-particle preparation and preparation method thereof; Dissolve in organic solvent with the lipid that is insoluble in water and constitute oil phase; Aqueous solution with ranitidine hydrochloride and hydrophilic surfactant active is a water; Adopt the even method that combines of stirring and emulsifying and high pressure breast the ranitidine hydrochloride bag is stated from the solid lipid nanoparticle mix with bismuth potassium citrate again; Make ranitidine hydrochloride bismuth potassium citrate pharmaceutical composition solid lipid nanoparticle at last solid lipid nanoparticle is processed solid preparation with general formulation method.Solid lipid nano-particle preparation drug loading provided by the invention is high particle diameter is even medicine retention time in blood circulation is long; Have better slow release and controlled-release effect and be beneficial to bismuth potassium citrate release to cover the effect of gastrointestinal ulceration surface performance ulcer interleaving agent.The equipment of method for preparing is simple and easy operating has improved the formulation products quality has reduced toxic and side effects is suitable for industrialized great production.

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