The invention belongs to the technical field of medicinal preparations and provides a preparation technique of a freeze-dried powder injection. The preparation technique comprises the following steps of cooling the prescription amount of 40%-90% of water for injection to 20-60 DEG C regulating or not regulating pH sequentially adding all prescription matters stirring measuring or regulating pH supplementing water adding active carbon of the prescription amount under the condition of temperature control stirring and decoloring filter pressing filtering and sterilizing thereby obtaining a sterile liquid medicine; and separately bottling by penicillin bottles carrying out freeze drying and capping through rolling thereby obtaining the freeze-dried powder injection. The preparation technique is simple to operate has short production cycle is applicable to industrial production prevents products from decomposing due to high temperature avoids slow compatibility of medicines is accurate in measuring products can produce products with a good appearance is beneficial to improvement of the stability of medicines and is convenient for long-term storage of medicines. The preparation technique is widely used for preparing freeze-dried powder injections of ligustrazine phosphate sodium ozagrel levocarnitine and omeprazole and the like.

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