The present invention relates to pharmaceutical technology field.The extracting method of apigenin of the present invention comprises the following steps: 1) take celery as substrate the mixing solutions that is respectively the polygalacturonase of 33%-37% and the glucuroide of 43%-47% with mass percent concentration enzymolysis 10 hours at 30-35 ℃; 2) by the ethanolic soln supersound extraction of step 1) gained enzymolysis product employing 70% extracting solution is concentrated and then sherwood oil and ethyl acetate extract respectively and by after extraction liquid evaporate to dryness the dissolve with ethanol with 70% finally uses high performance liquid chromatograph device separation and Extraction.The pharmaceutical composition that is used for the treatment of diabetes of the present invention comprises apigenin and acarbose and its mass ratio is 1:(2-5).The present invention utilizes multi-enzyme method to extract apigenin greatly improves the productive rate extracting.Pharmaceutical composition of the present invention can effectively control blood sugar can avoid again using merely hypoglycemia that diabetes drug treatment may bring and the patient body weight too fast situation that declines simultaneously.

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