The present invention relates to a kind of chewing gum of preventing and treating oral ulcer after the chemotherapy and preparation method thereof this chewing gum is made up of chewing gum batching and control stomatocace medicine per 100 grams are prevented and treated and are contained the control stomatocace medicine in the chewing gum of oral ulcer after the chemotherapy and be respectively: 5～10 milligrams of recombinant human granulocyte colony stimulating factors 5～10 milligrams in folic acid 5～10 milligrams of metronidazoles 20～50 milligrams of lignocaine 5～20 milligrams of cimetidine vitamin B2: 2.5～10 milligrams surplus is the chewing gum batching; The percentage by weight of each component is respectively in the described chewing gum batching: edible gum base 25～30% maltose syrup 20～25% xylitol 35～45% Sorbitol 10～20%.Chewing gum of the present invention can be prevented and treated the oral ulcer that the different causes of disease cause after the chemotherapy effectively; Can also reduce medicine stimulates gastrointestinal reduces the generation of untoward reaction increases safety; Mouthfeel is good taking convenience.

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