The invention discloses a kind of synthetic method of diabetes medicament glimepiride compound 3(material name: N-4-［ 2-(3-ethyl-4-methyl-2-oxidation-3-pyrroline-1-formamido-) ethyl ］-benzsulfamide) and compound 2(title its innovative point is:: oppose methylcyclohexyl amine) logical at low temperatures phosgene reaction through aftertreatment acetone refining obtains finished product.Technique of the present invention is simple easy to operate and product yield is high.

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