The invention relates to a pharmaceutical composition of paclitaxel and ranitidine hydrochloride and especially relates to an application product of the pharmaceutical composition wherein the application product comprises paclitaxel injection and an injection containing ranitidine hydrochloride. Administration comprises following steps the injection containing ranitidine hydrochloride is applied firstly by intravenous injection the paclitaxel injection is dissolved and diluted by normal saline or 5% glucose and sodium chloride solution and then the diluted paclitaxel injection is applied by intravenous drop infusion.

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