The invention provides a cimetidine composition for injection and relates to the technical field of medicines and medicine manufacturing. Main medicines of the composition are cimetidine and melatonin. The melatonin comprises a quick release part and a slow release part contained in cyclodextrin. The cimetidine composition for injection provided by the invention has the functions of improving the treatment effect on upper gastrointestinal hemorrhage shortening the course of treatment further reducing the use level of cimetidine and lowering the side effect of cimetidine. Instability fast distribution and elimination and the like of MT (Melatonin) caused by oral absorption are avoided and the first pass effect of MT is reduced. Delivery design combining quick release and slow release meets the secretion characteristic of MT solves the problem of short half life of MT and improves the bioavailability of the product.

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