The invention provides a famotidine composition for injection and relates to the technical field of medicine manufacturing. The main medicine of the composition comprises famotidine and melatonin wherein the melatonin comprises a quick release part and a cyclodextrin-included slow release part. According to the famotidine composition for injection provided by the invention the therapeutic effect of famotidine is improved instability caused by oral administration of MT (Melatonin) is avoided and MT is quick to distribute and eliminate and the like and the first pass effect of MT is reduced. The design of dosage combining quick release and slow release is in accordance with secretion characteristic of MT so that the problem of half-life period of MT is solved and the bioavailability of melatonin is improved. Melatonin combined with famotidine can be used for effectively inhibiting the secretion of gastric acid so that the composition has a good synergistic effect for treating benign active gastric ulcer.

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