The invention discloses a kind of compound medicine of preventing and treating avian enteritis it contains the following component of amount by mass percentage: antibiotic 10～40% diarrhea 0.1～1% intestinal mucosa protective agent 2～12% surplus is adjuvant.Antibiotic in component of the present invention is one or more components in aminoglycosides polymyxin class and berberine hydrochloride.Described diarrhea is one or more combinations in scopolamine methobromide atropine diphenoxylate loperamide bismuth subnitrate.Described intestinal mucosa protective agent is one or more combinations in vitamin K3 cimetidine glutamine.Described adjuvant is one or more combinations in oral glucose anhydrous glucose soluble starch dextrin cyclodextrin.The present invention also comprises the preparation method of the compound medicine of preventing and treating avian enteritis.

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