The invention belongs to medical technical field be specifically related to a kind of omeprazole sodium compound and the preparation method of this omeprazole sodium compound.The X-ray powder diffraction spectrogram that described omeprazole sodium compound use Cu-K alpha-ray measures as shown in Figure 1.The preparation method of described omeprazole sodium compound comprises the following steps: get Omeprazole Sodium crude product add DMF to be made into saturated solution then be incorporated as the ether of DMF volume 1/10-1/8 stir with sodium hydroxide regulate pH to 7-8 be placed in reactor sealing is heated to 155-180 ℃ and be incubated 2-3 days standing and be naturally cooled to room temperature drive still under agitation condition add ether carry out crystallization filter washing dry.Omeprazole sodium compound provided by the invention has excellent mobility is difficult for drawing wet and physicochemical property is excellent.

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