The invention provides a kind of injection levofloxacin composite freeze-dried powder relate to medicine and medicine manufacture technology field comprise following weight portion material composition: 1.75～2.14 parts of Esomeprazole sodiums 0.87～1.07 part of chitosan nano 94.80～97.38 parts of waters for injection.Advantage of the present invention is: 1) overcome the problem of principal agent poor stability be conducive to Long-term Storage; 2) said composition has synergism in vivo can treat gastric ulcer gastro oesophageal reflux disease (GORD) duodenal ulcer etc. clinically curative effect is rapid through in vitro tests checking the 40mg Esomeprazole sodium of chitosan-containing nanoparticle and not the gastric acid secretion inhibiting effect of the 60mg Esomeprazole sodium of chitosan-containing nanoparticle are equal to; 3) active enhancing is shortened patient's medication cycle has reduced Esomeprazole sodium and has caused the probability that untoward reaction occurs; 4) the alternative mannitol of chitosan nano as the lyophilizing skeleton agent of freeze-dried powder has been eliminated the active function of mannitol to human body.

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