The invention provides a kind of injection Pantoprazole Sodium composite freeze-dried powder relate to medicine and medicine manufacture technology field comprise following weight portion material composition: 7.24～9.08 parts of Pantoprazole Sodiums 4.34～5.45 parts of chitosan nanos 85.25～89.11 parts of waters for injection.Advantage of the present invention is: 1) in 1: 0.6(Pantoprazole Sodium: the compositions that chitosan nano) ratio forms has more powerful inhibitory action to H+-K+ATP enzyme; 2) can reduce Pantoprazole Sodium consumption clinically reduce Pantoprazole Sodium untoward reaction the 20mg Pantoprazole Sodium of chitosan-containing nanoparticle and not the gastric acid secretion inhibiting effect of the 30mg Pantoprazole Sodium of chitosan-containing nanoparticle are equal to; 3) improved medicine water solublity simultaneously also guaranteed that medicine has good stability; 4) drug-carrying nanometer particle can change film operative mechanism increases medicine to biomembranous permeability is conducive to medicine drug effect performance in cell; 5) the alternative mannitol of chitosan nano as the lyophilizing skeleton agent of freeze-dried powder has been eliminated the active function of mannitol to human body.

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