The invention aims at providing a pantoprazole sodium medicine composition for injection and a preparation method thereof. A certain amount of sodium calcium edentate meglumine and sodium hydroxide are selected and used the pH value of the solution is firstly regulated then the pantoprazole sodium is dissolved in the solution. The stability of the medicine composition can be effectively improved the medicine composition is not easy to dissolve out and related substances do not change. According to the new pantoprazole sodium medicine composition the problem of stability of the solution of the pantoprazole sodium in clinical application is thoroughly solved.

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