The invention provides a kind of injection Levpantoprazole Sodium composite freeze-dried powder relate to medicine and medicine manufacture technology field comprise following weight portion material composition: 8.26～10.05 parts of Levpantoprazole Sodiums 6.83～8.40 parts of chitosan nanos 81.25～87.11 parts of waters for injection.Advantage of the present invention is: 1) antiulcer action of said composition is obviously better than the Levpantoprazole Sodium of single component; 2) when with other medicines adapted safety and effectiveness all higher than similar omeprazole and lansoprazole selectivity to parietal cell is more single-minded not only can reduce Levpantoprazole Sodium consumption clinically and reduce Levpantoprazole Sodium untoward reaction; 3) said composition persistent period in blood extends greatly; 4) said composition can not only improve the dissolubility of Levpantoprazole Sodium in water and can shorten its dissolution time is conducive to clinical practice; 5) alternative mannitol of chitosan nano etc. is as freeze-dried excipient eliminated the active function to human body such as mannitol.

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