The invention provides a kind of cimetidine composition freeze-drying oral cavity disintegration tablet relate to medicine and medicine manufacture technology field comprise following weight portion material composition: cimetidine 200g～800g; Microcrystalline Cellulose (100 order) 150g～600g; Dextrin (100 order) 800g～4000g; Chitosan nano 50g～200g; Citric acid appropriate; Water for injection 1000mL～2000mL.Disintegration rate is fast dissolution rate is high good stability dosage is accurate content is even taking convenience be easy to carry and raw material is easy to get cost is low.The preparation method of cimetidine composition freeze-drying oral cavity disintegration tablet of the present invention is simple to operate easily controls and saving of work and time is beneficial to industrialized great production.

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